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A. Introduction

A1. Acute peripheral neuropathy

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์‹ ๊ฒฝ๊ทผ ์ ‘ํ•ฉ๋ถ€๊นŒ์ง€ ํ™•์žฅ๋˜๋Š” CNS ์™ธ๋ถ€์˜ ๊ฐ๊ฐ ๋ฐ ์šด๋™ ์„ฌ์œ ์˜ ์†์ƒ ๋˜๋Š” ์งˆ๋ณ‘์„ ์ˆ˜๋ฐ˜
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Acute peripheral lesion์„ ์˜์‹ฌํ•˜๊ธฐ ์ „์—, stroke ํ˜น์€ spinal cord injury ๊ฐ™์€ central process ๋ฅผ ๋จผ์ € ๊ณ ๋ คํ•ด์•ผ ํ•œ๋‹ค.

A2. Distinguishing central and peripheral lesion

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CNS disorder์™€ PNS disorder์˜ Hx, Sx, Sg, P/Ex์€ overlap์ด ์กด์žฌํ•œ๋‹ค.
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Aphasia, apraxia, vision loss๋Š” cortical disease์˜ ํŠน์ง•.
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Upper motor neuron sign : Hyperreflexia, Hypertonia (spasticity), Babinski reflex ์ด ์ค‘ lateralization of weakness, hyperreflexia, Babinski (+) โ†’ Central์„ ๋” ์‹œ์‚ฌํ•จ
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์•„๋งˆ๋„ ๊ฐ€์žฅ ์ค‘์š”ํ•œ ๊ตฌ๋ณ„ ์š”์†Œ๋Š” DTR ๊ฒ€์‚ฌ : Barbinski sign : Pyramidal tract์˜ ์ค‘์‹ฌ๋ถ€ ํŒŒ๊ดด ์˜๋ฏธ

A3. Localizing peripheral nerve lesions

(1) ๊ฒ€์‚ฌ

โ‘  EMG (Muscular vs N-M junction) โ‘ก NCV (Axonal loss vs Demyelination) โ‘ข CSF study (Acute or subacute inflammatory and infectious process) โ‘ฃ MRI, Nerve biopsy, etc..

(2) PNS disorder์˜ ์น˜๋ฃŒ โ†’ Depends on the specific diagnosis

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In ED : Supportive care, Monitoring (Respiratory failure, Aspiration, Dysarhythmias)
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Diaphragmatic failure risk๊ฐ€ ์žˆ๋Š” ํ™˜์ž๋Š” baseline FVC ํ˜น์€ negative inspiratory pressure๋ฅผ ์ธก์ •ํ•˜์—ฌ, vent ํ˜น์€ ICU care๊ฐ€ ํ•„์š”ํ•œ์ง€ ํŒŒ์•…!